Encompassing vast oil and gas resources, Iran has consistently been recognized as one of the primary energy players in the region and the world. The obligations of sustainable development and adaptation strategies to climate change have posed a serious quest for expanding investment in renewable energies to protect the environment from further adverse impacts of utilizing fossil fuels. In addition, the imbalance between water resources and consumption due to the excessive development of agricultural activities, together with the lack of proper management of urban and industrial effluents, has brought about a critical quantitative and qualitative condition of these resources in many parts of the country. Given the necessity of integrated management of water, energy, food, and environment, as well as considering the mission and roadmap of the Sharif University of Technology (SUT) for the sustainable development of the country, the Sharif Energy, Water and Environmental Institute (SEWEI) was established in 2019 by merging the Sharif Energy Research Institute, the Institute of Water and Energy, and the Research Institute of Biotechnology and Environment. Approved by the SUT’s Board of Trustees, SEWEI is currently governed by an independent Article of Association.